A Diabetic Foot Ulcer (DFU) is a serious complication of diabetes and can lead to a lower limb amputation if not treated properly and in an early stage. A DFU is often caused by poor blood circulation and neuropathy and therefore also heals poorly. For these long-term non-healing wounds, infection is a threat. If the wound does not heal or if an infection spreads, amputation is sometimes unavoidable. In recent years, research on automation using computer vision and Machine Learning methods plays an important role in DFU treatment. Promising successes have already been achieved so far. The aim of this project is to develop new Machine Learning techniques to assist in deciding whether amputation is a more suitable option at an early stage of the treatment.